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16/05/2016

Correlation between retinal demage in Age related macular degeneration and cardio-vascular patology in patients with cardio-vascular diseases

Автор
Aleksandrova S.
I Eye Clinic Hospital – Sofia
Рецензент: д-р Христина Видинова д.м.

ABSTRACT

Aim:
To find correspondence between the levels of retinal changes in age related macular degeneration cases and the gravity of the attendant cardiovascular disease.

Method:
Retrospective analysis of macular degeneration patient’s fluorescein angiograms and searching for comorbidity with internal diseases in the electronic archives of the Premier Municipal Hospital for Active Treatment in Sofia for the period November 2011 to June 2015, has been performed. For 31 patients diagnosed with macular degeneration, information for concomitant internal diseases was found. Our further study showed that 10 of the patients had serious cardiac impairments, 8 of them had also significant retinal changes. The patients with the pulmonary diseases had most severe retinal changes. We do not have information for their smoking habits.

Results:
All age related macular degeneration patients for which we found detailed information had arterial hypertension. Correspondence was observed between the severities of the retinal and the cardiovascular changes. The eyes of patients with a pulmonary disease were most significantly affected. The conclusions are not statistically significant because of the size of the group but they are relevant to various multinational studies. We have observations for which we could not find scientific articles worldwide. They will be on the found of our future researches.

LITERATURE

  1. Wong WL, Su X, Li X, Cheung CMG, Klein R, Cheng C-Y, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta- analysis. The Lancet Global Health. 2014;2(2):e106- e16.
  2. Pascolini D, Mariotti SP. Global estimates of visual impairment: 2010. The British journal of oph- thalmology. 2012 May;96(5):614-8. PubMed PMID: 22133988
  3.  The Framingham Eye Study Monograph: An Ophthalmological and Epidemiological Study of Cataract, Glaucoma, Diabetic Retinopathy, Macular Degeneration, and Visual Acuity in a General Popu- lation of 2631 Adults, 1973–1975, Kahn HA, Leibow- itz HM, Ganley JP, Kini MM, Colton T, Nickerson RS, Dawber TR, published by Survey of Ophthalmology (Surv Ophthalmol 24 (suppl): 335–610, 1980)
  4. Pathologies Oculaires Liées à l’Age POLA Study -Cécile Delcourt, PhD; Jean-Paul Cristol, MD; Frédéric Tessier, PhD; Claude L. Léger, PhD;Bernard Descomps, MD; Laure Papoz, PhD; and the POLA Study Group Arch.ophthalmol./vol.117, oct. 1999
  5. Hypertension, Cardiovascular Disease, and Age-Related Macular Degeneration, Leslie Hyman, PhD; Andrew P. Schachat, MD; Qimei He, PhD; M. Cristina Leske, MD, MPH ; for the Age-Related Mac- ular Degeneration Risk Factors Study Group
  6. Arch Ophthalmol. 2000;118(3):351-358. doi:10.1001/archopht.118.3.351.
    Vingerling JRHofman AGrobbee DEde Jong PT Age-related macular degeneration and smoking: the Rotterdam Study. Arch Ophthalmol. 1996;1141193-1196 Link to Article
  7. Smith WMitchell PLeeder SR Smoking and age- related maculopathy: the Blue Mountains Eye Study. Arch Ophthalmol. 1996;1141518- 1523
Posted in Diagnostics, Scientific by System Art | Tags:
10/05/2016

Case report of sympathetic ophthalmia, manifested with involvement of the anterior segment

Autors
V. Haykin, Y. Zdravkov, A. Oscar, Iv. Tanev
Clinic of Ophthalmology, University “Alexandrovska”Hospital, Sofia
Department of Ophthalmology, Medical Faculty, Medical University – Sofia

Abstract
Sympathetic ophthalmia is a bilateral, T-cell mediated, diffuse granulomatous intraocular inflammation, occurring after a penetrating injury of the eye or following a surgery. The clinical manifestations vary from mild visual loss to total blindness.  In 80% of the cases it is observed within the first 3 months and in 90% within the first year after the accident. The diagnosis is based on medical history and clinical examinations. There are no specific laboratory tests.

We present a case report of a 71 year old male patient with an atypical presentation of sympathetic ophthalmia, involving only the anterior eye segment, without affecting the posterior segment.

In case of severe eye injury, without perspective for preservation or recovery of visual function of the injured eye, inability to restore the integrity of the eye layer by layer and lack of aesthetic function, primary enucleation should be considered. Despite the positive results, the best treatment is prevention.

vasil_2f

Ляво око – състояние след тридневно лечение

vasil-1f

Дясно око – претърпяло травма

LITERATURE
Arevalo JF, Garcia RA, Al-Dhibi HA, Sanchez JG, Suarez-Tata L. Update on sympathetic ophthalmia. Middle East Afr J Ophthalmol. 2012;(1):13-21.

  1. Kase S1, Meghpara BB, Ishida S, Rao NA. Expression of α-crystallin in the retina of human sympathetic ophthalmia. Mol Med Rep. 2012;(2):395-9. Kase S1, Meghpara BB, Ishida S, Rao NA. Expression of α-crystallin in the retina of human sympathetic ophthalmia. Mol Med Rep. 2012;(2):395-9.
  2. Chen S, Aronow ME, Wang C, Shen D, Chan C-C. Classical Pathology of Sympathetic Ophthalmia Presented in a Unique Case. The Open Ophthalmology Journal. 2014;(8):32-38.
  3. Wang Y1, Chan CC2. Gender differences in vogt-koyanagi-harada disease and sympathetic ophthalmia. J Ophthalmol. 2014:157803.
  4. Chu XK1, Chan CC. Sympathetic ophthalmia: to the twenty-first century and beyond. J Ophthalmic Inflamm Infect. 2013;3:49.
  5. Jiménez J1, Olea J, Torres J, Alonso I, Harder D, Fischer K. Biography of louis braille and invention of the braille alphabet. Surv Ophthalmol. 2009;54(1):142-9.
  6. Al-Dhibi HA1, Al-Mahmood AM2, Arevalo JF3. A systematic approach to emergencies in uveitis. Middle East Afr J Ophthalmol. 2014;21(3):251-8.
  7. Cha DM1, Woo SJ, Ahn J, Park KH. A case of sympathetic ophthalmia presenting with extraocular symptoms and conjunctival pigmentation after repeated 23-gauge vitrectomy. Ocul Immunol Inflamm. 2010;(4):265-7.
  8. Fankhauser F1, Kwasniewska S, Van der Zypen E. Cyclodestructive procedures. I. Clinical and morphological aspects: a review. Ophthalmologica. 2004;218(2):77-95.
  9. Akram S1, Khabir K1. Vogt-Koyanagi-Harada syndrome. J Coll Physicians Surg Pak. 2014;24(9):692-4.
  10. van Velzen GA1, Verwer KM, Rothova A, Gilhuis HJ. Vogt-Koyanagi-Harada syndrome. Ned Tijdschr Geneeskd. 2015;159(0):A8614.
  11. Mercan M, Akyol A, Karaman Y, Bolay H. A case of sarcoidosis of the central nervous system and orbita. Case Rep Med. 2015;2015:403459.
  12. Chaithanyaa N1, Devireddy SK, Kishore Kumar RV, Gali RS, Aneja V. Sympathetic ophthalmia: a review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113(2):172-6.
  13. Croxatto JO, Rao NA, McLean IW, Marak GE. A typical histopathologic features in sympathetic ophthalmia. A study of a hundred cases. Int Ophthalmol 1982; 4(3): 129-35.
  14. Коев К., И. Каменов и В. Велчев. Ефективност на високодозираната кортикостероидна пулсова терапия при възпалителни очни заболявания.   – Офталмология РБ (Варна), 12, 2005, № 5, с. 20-27.
  15. 16. Петкова Анна.   Детски очни травми – епидемиологични и клинични проучвания.   Автореферат.   С.,МУ-София,2011, 44с.
Posted in Scientific by Д-р Васил Хайкин | Tags: , ,